Pathologisches Institut
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AG Steffen Ormanns

Research outline

Our research projects focus mainly on pancreatic cancer and other gastrointestinal malignancies.
Pancreatic ductal adenocarcinoma is a devastating disease with mortality rates close to incidence rates. The majority of pancreatic cancer is detected at an advanced stage, when metastasis occurred. In a minority of the cases, curative intent surgical resection is an option or resectability can be achieved by neoadjuvant chemotherapy.
In our group, there are two major lines of research:

  1. Translational research projects are carried out in close cooperation with the oncology research group (“AG Onkologie”) at the Department of Internal Medicine III, University Hospital Großhadern (Prof. Stefan Böck, Prof. Volker Heinemann). To identify possible novel therapeutic targets, we study the association of biomarkers, such as protein expression or mutational status of oncogenes to the patients´ clinical outcome and therapy response in advanced pancreatic cancer as well as resected pancreatic cancer.
  2. Additionally, we extend, further examine and confirm these findings in a basic line of research, using a broad spectrum of cell culture methods. Thus, we want to elucidate the functional implications of biomarkers in the biologic behavior of pancreatic cancer cells, focusing on malignant traits and chemotherapy resistance.

We are a translational research group working as a link between clinical and basic research. Our overall goal is to improve the outcome and therapy of patients affected by pancreatic cancer and other malignant solid gastrointestinal tumors through identification of possible novel therapeutic targets or predictive biomarkers.

Team

Steffen Ormanns, Dr. med.
principal investigator

 

 

 

 

Sibylle Bächmann, pathology resident
Michael Günther, cand. med., MD thesis student
Lina Gil, cand.med., MD thesis student
Melanie Alexandra Palm, cand.med., MD thesis student
Liou iduna, M.Sc. cand. student

 

Cooperations

AG Onkologie (Oncology research group)
Department of Internal Medicine III and Comprehensive Cancer Center LMU (CCCLMU)

Prof. Dr. Stefan Böck
Prof. Dr. Volker Heinemann
Dr. med. Michael Haas
Dr. med. Stephan Kruger
Dr. med. Christoph Benedikt Westphalen

MD thesis students in cooperation projects

Anna Remold, cand.med.
Verena Rösgen, cand.med.
Philipp Burger, cand.med.
Anna Preinfalk, cand.med.

Publications

Funding

Friedrich-Baur-Stiftung, Munich

 Verein zur Förderung von Wissenschaft und Forschung an der Medizinischen Fakultät der Ludwig-Maximilians-Universität

 

(Stand:20.04.2018)